01 - In a small bowl, combine the salt, black pepper, paprika, garlic powder, and onion powder. Mix well to ensure even distribution of spices.
02 - Pat the tilapia fillets dry with paper towels. Sprinkle both sides of each fillet evenly with the prepared seasoning blend.
03 - For a crispier crust, lightly dredge the seasoned fillets in cornmeal or gluten-free flour, shaking off any excess coating.
04 - Heat the olive oil or butter in a large nonstick skillet over medium-high heat until the oil shimmers or the butter stops foaming.
05 - Carefully place the fillets in the hot skillet, working in batches if necessary to avoid crowding. Cook for 3 to 4 minutes on the first side until golden and the fish releases easily from the pan.
06 - Gently flip each fillet using a fish spatula and cook for another 2 to 3 minutes until the fish is opaque throughout and flakes easily with a fork.
07 - Transfer the pan-fried tilapia to serving plates immediately. Garnish with fresh lemon wedges for squeezing over the fish.